welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
MutYH The Base Excision Repair Gene Family Member Associated with Colorectal Cancer Polyposis
source: Gastroenterology and hepatology from bed to bench
year: 2013
authors: Kashfi S M, Golmohammadi M, Behboudi F, Nazemalhosseini-Mojarad E, Zali M R
summary/abstract:COLORECTAL CANCER IS CLASSIFIED IN TO THREE FORMS:
sporadic (70-75%), familial (20-25%) and hereditary (5-10%). hereditary colorectal cancer syndromes classified into two different subtypes: polyposis and non polyposis. Familial Adenomatous polyposis (FAP; OMIM #175100) is the most common polyposis syndrome, account for <1% of colorectal cancer incidence and characterized by germline mutations in the Adenomatous polyposis coli (APC, 5q21- q22; OMIM #175100). FAP is a dominant cancer predisposing syndrome which 20-25% cases are de novo. There is also another polyposis syndrome; MUTYH associated polyposis (MAP, OMIM 608456) which it is caused by mutation in human Mut Y homologue MUTYH (MUTYH; OMIM 604933) and it is associated with multiple (15-100) colonic adenomas. In this paper we discuss MUTYH mechanism as an important member of Base Excision Repair (BER) family and its important role in polyposis condition.
read more
expertly curated content related to this topic
-
Unusual Cancers of Childhood TreatmentThere are two adrenal glands. The adrena...
-
Polishing the Crystal Ball: Knowing Genotype Improves Ability to Predict Desmoid Disease in Patients with Familial A...INTRODUCTION : Desmoid disease occurs in...
-
Papillary Thyroid Cancer in a Patient with MUTYH-Associated Polyposis (MAP)We describe a patient with MUTYH-associa...
-
MutY, E. Coli, Homolog of; MUTYHA summary of mutY/MYH/MUTYH...
-
MYH-Associated PolyposisMYH-associated polyposis is an inherited...
-
Hereditary Colorectal Cancer Syndromes and Genetic TestingColorectal cancer (CRC) is a leading cau...
-
F.A.P.ology101: What’s in a name?https://www.youtube.com/watch?v=Om8V-mQl...