welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Nutritional Agents With Anti-inflammatory Properties in Chemoprevention of Colorectal Neoplasia
source: Recent results in cancer research
year: 2013
authors: Hull M A
summary/abstract:The strong link between inflammation and colorectal carcinogenesis provides the rationale for using anti-inflammatory agents for chemoprevention of colorectal cancer (CRC). Several naturally occurring substances with anti-inflammatory properties, used in a purified ‘nutraceutical’ form, including omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and polyphenols such as curcumin and resveratrol, have been demonstrated to have anti-CRC activity in preclinical models. As expected, these agents have an excellent safety and tolerability profile in Phase II clinical trials. Phase III randomized clinical trials of these naturally occurring substances are now beginning to be reported. The omega-3 polyunsaturated fatty acid EPA, in the free fatty acid (FFA) form, has been demonstrated to reduce adenomatous polyp number and size in patients with familial adenomatous polyposis (FAP), a finding which has prompted evaluation of this formulation of EPA for prevention of ‘sporadic’ colorectal neoplasia. Anti-inflammatory ‘nutraceuticals’ require further clinical evaluation in polyp prevention trials as they exhibit many of the characteristics of the ideal cancer chemoprevention agent, including safety, tolerability and patient acceptability.
organization: St James's University HospitalDOI: 10.1007/978-3-642-30331-9_8
read more
expertly curated content related to this topic
-
Discrepancies in Biopsy Results in Pre- Versus Post-Endoscopic AmpullectomiesAbstract Purpose: Endoscopic ampullec...
-
Our Experience of Treatment of Cribriform Morular Variant of Papillary Thyroid Carcinoma; Difference in Clinicopatho...Cribriform-morular variant (CMV) is a co...
-
Evaluation of 28 Years of Surgical Treatment of Children and Young Adults with Familial Adenomatous PolyposisBACKGROUND : In this retrospective study...
-
Sulindac Sulfone Induced Regression of Rectal Polyps in Patients with Familial Adenomatous PolyposisSulindac sulfone (Exisulind), a metaboli...
-
Curcumin in Treating Patients With Familial Adenomatous PolyposisThis clinical trial studies curcumin in ...
-
Risk-Reducing Surgery in FAP: Role for Surgeons Beyond the IncisionBACKGROUND : Although primary therapy in...
-
Shrinking the SilenceI’m a 28 year old, living with two ver...