source: Journal of gastroenterology and hepatology

year: 2015

authors: Fabiana Tolentino Almeida, Camila Pachêco-Pereira, André Luís Porporatti, Carlos Flores-Mir, Graziela De Luca Canto, Eliete Neves Silva Guerra, André Ferreira Leite

BACKGROUND AND AIM : The oral manifestations of Familial Adenomatous Polyposis (FAP) have been reported in the recent literature. Therefore, there has been growing interest in the characterization of the dento-osseous anomalies because they may precede colorectal cancer and maybe used as a diagnostic marker. This systematic review and meta-analysis was performed to evaluate the published evidence for what are the oral manifestations of FAP and their frequency in affected individuals.

METHODS : The search was performed at Cochrane Library, EMBASE, LILACS, PubMed, Scopus and Web of Science for articles published up to March 2015. A grey literature search was conducted through Google Scholar. References lists of the included articles and additional studies identified by expert were screened for potential relevant studies. The methodology of selected studies was evaluated using the risk of bias checklist of the Agency for Healthcare Research and Quality (AHRQ).

RESULTS : Twenty observational studies totalizing 1,635 individuals affected by FAP met the inclusion criteria. Osseous, dental and oral mucosa alterations were observed in FAP patients. The meta-analysis showed the frequency of osseous jaw lesions and the dental anomalies was 65.35% and 30.48%, respectively and two studies suggested that oral mucosa vascular density is a phenotypic manifestation in patients with FAP. Most of the studies were evaluated as moderate risk of bias.

CONCLUSION : The most frequent oral manifestation on FAP patients is osseous jaw alterations. In the future, well-designed studies are necessary to classify osseous and dental anomalies in order to demonstrate the true prevalence of each alteration separately.