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scientific articles

Pancreaticoduodenectomy for Advanced Duodenal and Ampullary Adenomatosis in Familial Adenomatous Polyposis

key information

source: HPB journal

year: 2011

authors: James R. A. Skipworth, Clare Morkane, Dimitri Aristotle Raptis, Soumil Vyas, Charles J. Imber, Stephen P. Pereira, Steven W. Olde Damink, Massimo Malago


BACKGROUND : Patients with familial adenomatous polyposis (FAP) develop duodenal and ampullary polyps that may progress to malignancy via the adenoma-carcinoma sequence.

OBJECTIVE : The aim of this study was to review a large series of FAP patients undergoing pancreaticoduodenectomy for advanced duodenal and ampullary polyposis.

METHODS : A retrospective case notes review of all FAP patients undergoing pancreaticoduodenectomy for advanced duodenal and ampullary adenomatosis was performed.

RESULTS : Between October 1993 and January 2010, 38 FAP patients underwent pancreaticoduodenectomy for advanced duodenal and ampullary polyps. Complications occurred in 29 patients and perioperative mortality in two. Postoperative histology revealed five patients to have preoperatively undetected cancer (R = 0.518, P < 0.001).

CONCLUSIONS : Pancreaticoduodenectomy in FAP is associated with significant morbidity, but low mortality. All patients under consideration for operative intervention require careful preoperative counselling and optimization.

organization: Royal Free Hampstead NHS Trust

DOI: 10.1111/j.1477-2574.2011.00292.x

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