welcome to oneFAPvoice- a positively charged Familial Adenomatous Polyposis community.
- join today!
Pancreaticoduodenectomy for Advanced Duodenal and Ampullary Adenomatosis in Familial Adenomatous Polyposis
source: HPB journal
authors: James R. A. Skipworth, Clare Morkane, Dimitri Aristotle Raptis, Soumil Vyas, Charles J. Imber, Stephen P. Pereira, Steven W. Olde Damink, Massimo Malagosummary/abstract:
BACKGROUND : Patients with familial adenomatous polyposis (FAP) develop duodenal and ampullary polyps that may progress to malignancy via the adenoma-carcinoma sequence.
OBJECTIVE : The aim of this study was to review a large series of FAP patients undergoing pancreaticoduodenectomy for advanced duodenal and ampullary polyposis.
METHODS : A retrospective case notes review of all FAP patients undergoing pancreaticoduodenectomy for advanced duodenal and ampullary adenomatosis was performed.
RESULTS : Between October 1993 and January 2010, 38 FAP patients underwent pancreaticoduodenectomy for advanced duodenal and ampullary polyps. Complications occurred in 29 patients and perioperative mortality in two. Postoperative histology revealed five patients to have preoperatively undetected cancer (R = 0.518, P < 0.001).
CONCLUSIONS : Pancreaticoduodenectomy in FAP is associated with significant morbidity, but low mortality. All patients under consideration for operative intervention require careful preoperative counselling and optimization.organization: Royal Free Hampstead NHS Trust
read more full text source
expertly curated content related to this topic
High-Dose Tamoxifen and Sulindac as First-Line Treatment for Desmoid TumorsBACKGROUND : Desmoid tumors are mesenchy...
Chemoprevention in Familial Adenomatous PolyposisFamilial adenomatous polyposis (FAP) pre...
Familial Risk-Colorectal Cancer: ESMO Clinical Practice GuidelinesLynch syndrome is the most common heredi...
Eicosapentaenoic Acid Reduces Rectal Polyp Number and Size in Familial Adenomatous PolyposisOBJECTIVE : The omega-3 polyunsaturated ...
Shrinking the SilenceI’m a 28 year old, living with two ver...