welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Pathways of Colorectal Carcinogenesis
source: Applied immunohistochemistry & molecular morphology
year: 2013
authors: Arends M J
summary/abstract:This review of the molecular and cellular changes in the different pathways of colorectal carcinogenesis sets out the classic adenoma-carcinoma sequence of the large bowel as a stepwise series of pathologic neoplastic changes associated with accumulation of genetic and epigenetic molecular alterations. The 2 major types of genomic instability found in colorectal cancers are chromosomal instability (CIN) and microsatellite instability (MSI). CIN is often associated with mutated APC. MSI is due to defective DNA mismatch repair. The associated familial cancer susceptibility syndromes are familial adenomatous polyposis coli, due to inherited APC mutations, and Lynch Syndrome or hereditary nonpolyposis colorectal cancer syndrome, due to inherited mutations in one of the mismatch repair genes (predominantly MLH1 and MSH2). In the CpG island methylator phenotype, a number of genes become transcriptionally silenced because of hypermethylation of their promoters, and this represents a key epigenetic mechanism of inactivation of tumor suppressor genes, including certain DNA repair genes. An overview of the contributions of CIN, MSI, and CpG island methylator phenotype to the different pathways of colorectal carcinogenesis allows categorization of colorectal cancers into 5 major groups on the basis of their molecular and pathologic characteristics.
organization: University of CambridgeDOI: 10.1097/PAI.0b013e31827ea79e
read more full text source
expertly curated content related to this topic
-
The Wnt/Beta-Catenin Pathway and Familial Adenomatous Polyposis Part 3https://www.youtube.com/watch?v=H2LzPH8H...
-
Familial Adenomatous Polyposis by Luke Pardyhttp://www.slideshare.net/asteinman/fami...
-
Familial Adenomatous Polyposis 1This description of FAP1 discusses clini...
-
Colorectal Carcinomas, A Consideration on MutYH-Associated PolyposisColorectal cancer (CRC) is the second mo...
-
Targeting Wnt Signaling in Colorectal Cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanis...The evolutionarily conserved Wnt signali...
-
Familial Adenomatous Polyposis (FAP)An overview of FAP and literature analys...
-
Colorectal Polyps in ChildhoodPURPOSE OF REVIEW: Colorectal polyps ar...