Pharmacotherapy for Inherited Colorectal Cancer | oneFAPvoice

welcome to oneFAPvoice

- a positively charged Familial Adenomatous Polyposis community.
  • join today!
scientific articles

Pharmacotherapy for Inherited Colorectal Cancer

key information

source: Expert opinion on pharmacotherapy

year: 2010

authors: Lynch P M

summary/abstract:

IMPORTANCE OF THE FIELD : An important recent consideration in the medical management of colorectal cancer risk has been the notion of primary prevention or ‘chemoprevention’ of adenomas. A number of promising agents, and even combinations of agents, have shown promise in clinical trials. This review is written in the interest of capturing the current state of chemoprevention in familial adenomatous polyposis (FAP). This will take a decidedly clinical perspective.

AREAS COVERED IN THIS REVIEW : This review addresses mainly randomized clinical chemoprevention trials. A search using PubMed from 1980 to present was conducted.

WHAT THE READER WILL GAIN : The reader should gain an appreciation of the role that chemoprevention clinical trials in FAP has had in establishing a basis for clinically oriented use of selected drugs, mainly sulindac and celecoxib, as adjuncts to surgical and endoscopic treatment. In addition, the reader will see how FAP trials can provide a foundation for similar trials in nonfamilial adenomas.

TAKE-HOME MESSAGE : As a proving ground for new, potential chemopreventive agents, trials in FAP involved short-term (3- to 12-month) administration of drug. Endpoints generally involved measures of adenoma regression in the rectal segment retained post-colectomy.

organization: The University of Texas MD Anderson Cancer Center

DOI: 10.1517/14656561003698123

read more full text source

expertly curated content related to this topic

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close