welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Polymorphisms in The Adenomatous Polyposis Coli (APC) Gene and Advanced Colorectal Adenoma Risk
source: European journal of cancer
year: 2010
authors: Wong H L, Peters U, Hayes R B, Huang W Y, Schatzkin A, Bresalier R S, Velie E M, Brody L C
summary/abstract:While germline mutations in the adenomatous polyposis coli (APC) gene cause the hereditary colon cancer syndrome (familial adenomatous polyposis (FAP)), the role of common germline APC variants in sporadic adenomatous polyposis remains unclear. We studied the association of eight APC single nucleotide polymorphisms (SNPs), possibly associated with functional consequences, and previously identified gene-environment (dietary fat intake and hormone replacement therapy (HRT) use) interactions, in relation to advanced colorectal adenoma in 758 cases and 767 sex- and race-matched controls, randomly selected from the screening arm of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Cases had at least one verified advanced adenoma of the distal colon; controls, a negative sigmoidoscopy. We did not observe an association between genotypes for any of the eight APC SNPs and advanced distal adenoma risk (P(global gene-based)=0.92). Frequencies of identified common haplotypes did not differ between cases and controls (P(global haplotype test)=0.97). However, the risk for advanced distal adenoma was threefold higher for one rare haplotype (cases: 2.7%; controls: 1.6%) (odds ratio (OR)=3.27; 95% confidence interval (CI)=1.08-9.88). The genetic association between D1822V and advanced distal adenoma was confined to persons consuming a high-fat diet (P(interaction)=0.03). Similar interactions were not observed with HRT use. In our large, nested case-control study of advanced distal adenoma and clinically verified adenoma-free controls, we observed no association between specific APC SNPs and advanced adenoma. Fat intake modified the APC D1822V-adenoma association, but further studies are warranted.
organization: National Cancer Institute RockvilleDOI: 10.1016/j.ejca.2010.04.020
read more full text source
expertly curated content related to this topic
-
Clinical Practice Guidelines for Surveillance Colonoscopy – in Adenoma Follow-up; Following Curative Resection of ...SUMMARY OF CLINICAL PRACTICE RECOMMENDAT...
-
Unusual Cancers of Childhood TreatmentThere are two adrenal glands. The adrena...
-
Inherited Colorectal Cancer Syndromes – Diagnosis and ManagemntColorectal cancer is the most common gas...
-
Germline and Somatic Mutations of the APC Gene in Papillary Thyroid Carcinoma Associated with Familial Adenomatous P...Patients with familial adenomatous polyp...
-
Familial Adenomatous Polyposis and Other Polyposis SyndromesThis book discusses Familial Adenomatou...
-
Wireless Capsule Endoscopy in Adolescents with Familial Adenomatous PolyposisAIMS AND BACKGROUND: Guidelines for sur...
-
New Brunswick Colon Cancer Screening Clinical Practice GuidelinesThe New Brunswick Cancer Network (NBCN) ...