welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Pouch-Anal Anastomosis vs Straight Ileoanal Anastomosis in Pediatric Patients: A Meta-Analysis
source: Journal of pediatric surgery
year: 2006
authors: Henry S. Tilney, Vasilis Constantinides, Adonis S. Ioannides, Paris P. Tekkis, Munther J. Haddad, Ara W. Darzi
summary/abstract:BACKGROUND : Restorative proctocolectomy is the treatment of choice for pediatric patients with refractory colitis, inherited polyposis syndromes, and some with colonic aganglionosis. Evidence concerning the optimal method of reconstruction is, however, sparse.
METHODS : Studies comparing outcomes from ileal pouch-anal anastomosis (IPAA) and straight ileoanal anastomosis (SIAA) were identified by searching Medline, Ovid, and Embase. Suitable studies were selected and data extracted for meta-analysis.
RESULTS : Of 13 studies identified by literature search, 5 satisfied the inclusion criteria, comprising a total of 306 patients, 86 of whom (28.1%) underwent SIAA, and the remainder, IPAA. Pouch failure was more common in the SIAA group (odds ratio, 3.21; confidence interval, 1.24-8.34), as were abdominal salvage procedures (odds ratio, 9.5; confidence interval, 3.14-28.77). Short-term adverse events were similar between the 2 groups, with the exception of perianal sepsis, the higher frequency of which, in SIAA, just reached statistical significance. Bowel frequency was lower in the IPAA patients, although few studies presented functional data in a comparable form.
CONCLUSIONS : There are few good-quality studies that compare the outcomes from SIAA and IPAA, meaning that caution should be exercised in the generalization of the results of this meta-analysis, which suggests pouch procedures to be favorable in terms of reconstruction survival and functional outcome.
organization: Imperial College Londonread more full text source
expertly curated content related to this topic
-
Familial Risk-Colorectal Cancer: ESMO Clinical Practice GuidelinesLynch syndrome is the most common heredi...
-
Education and Management of Patients with Familial Adenomatous Polyposis. Are We Making Progress? A Case ReportAbstract: A 25-year-old male patient was...
-
Prostanoids, Ornithine Decarboxylase, and Polyamines in Primary Chemoprevention of Familial Adenomatous PolyposisBACKGROUND & AIMS : Familial adenoma...
-
Ileostomy: A GuideIleostomy surgery is done for many diffe...