welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Primary Chemoprevention of Familial Adenomatous Polyposis with Sulindac
source: The New England journal of medicine
year: 2002
authors: Giardiello F M, Yang V W, Hylind L M, Krush A J, Petersen G M, Trimbath J D, Piantadosi S, Garrett E, Geiman D E, Hubbard W, Offerhaus G J, Hamilton S R
summary/abstract:BACKGROUND : Familial adenomatous polyposis is caused by a germ-line mutation in the adenomatous polyposis coli gene and is characterized by the development of hundreds of colorectal adenomas and, eventually, colorectal cancer. Nonsteroidal antiinflammatory drugs can cause regression of adenomas, but whether they can prevent adenomas is unknown.
METHODS : We conducted a randomized, double-blind, placebo-controlled study of 41 young subjects (age range, 8 to 25 years) who were genotypically affected with familial adenomatous polyposis but phenotypically unaffected. The subjects received either 75 or 150 mg of sulindac orally twice a day or identical-appearing placebo tablets for 48 months. The number and size of new adenomas and side effects of therapy were evaluated every four months for four years, and the levels of five major prostaglandins were serially measured in biopsy specimens of normal-appearing colorectal mucosa.
RESULTS : After four years of treatment, the average rate of compliance exceeded 76 percent in the sulindac group, and mucosal prostaglandin levels were lower in this group than in the placebo group. During the course of the study, adenomas developed in 9 of 21 subjects (43 percent) in the sulindac group and 11 of 20 subjects in the placebo group (55 percent) (P=0.54). There were no significant differences in the mean number (P=0.69) or size (P=0.17) of polyps between the groups. Sulindac did not slow the development of adenomas, according to an evaluation involving linear longitudinal methods.
CONCLUSIONS : Standard doses of sulindac did not prevent the development of adenomas in subjects with familial adenomatous polyposis.
organization: Johns Hopkins University School of Medicineread more full text source
expertly curated content related to this topic
-
How to Defy a Hereditary Predisposition and Prevent Colon Cancerhttps://www.youtube.com/watch?v=IynYbT2i...
-
Clinical End Points for Developing Pharmaceuticals to Manage Patients with a Sporadic or Genetic Risk of Colorectal ...To reduce the morbidity and mortality fr...
-
Ileal Reservoir with Ileo-Anal Anastomosis: Long-term ComplicationsColoproctectomy with ileo-anal anastomos...
-
A Useful Reconstruction Arrangement Following Whipple’s Resection for Patients with Familial Adenomatous Polyp...BACKGROUND Peri-ampullary carcinoma i...
-
Relationship Between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in D...A few familial adenomatous polyposis stu...
-
The J-Pouch Group Dietary GuidelinesGood nutrition plays an essential role i...
-
Familial Adenomatous Polyposis. Laparoscopic Total Proctocolectomy with J-Pouch Ileoanal Anastomosishttps://www.youtube.com/watch?v=4l1qS1wa...