welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Randomized, Placebo-Controlled Trial of Gastric Acid-Lowering Therapy on Duodenal Polyposis and Relative Adduct Labeling in Familial Adenomatous Polyposis
source: Diseases of the colon and rectum
year: 2001
authors: Wallace M H, Forbes A, Beveridge I G, Spigelman A D, Venitt S, Phillips R K, Hewer A
summary/abstract:PURPOSE : Bile has been implicated in the pathogenesis of duodenal polyps in patients with familial adenomatous polyposis. In vitro experiments have shown that familial adenomatous polyposis bile is capable of producing DNA adducts. This effect can be ameliorated by increasing the pH of the incubate. The aim of this double-blind randomized placebo-controlled trial was to examine the effect of oral ranitidine on duodenal polyposis in a group of patients with familial adenomatous polyposis.
METHODS : Twenty-six patients with familial adenomatous polyposis were randomly assigned to ranitidine 300 mg daily or placebo for six months after baseline endoscopy. Polyp counts were performed and biopsy specimens taken to detect DNA adducts by 32P-postlabeling.
RESULTS : No difference was seen in polyp numbers (P = 0.9) or relative adduct labeling (P = 0.7) after treatment with ranitidine or placebo.
DISCUSSION : Acid suppression therapy does not seem to improve duodenal polyposis despite in vitro findings. On the other hand, ranitidine does not exacerbate actual (or markers of) neoplasia in this highly tumor-prone condition.
organization: St. Mark's Hospital Harrowread more
expertly curated content related to this topic
- Familial Adenomatous Polyposis by Douglas Riegert Johnsonhttp://www.slideshare.net/douglasriegert...
- New Combination Therapy Can Benefit Metastatic Colon CancerNew Combination Therapy Can Benefit Meta...
- Could APC Gene Screening be Useful in Children with Hepatoblastoma? Early Onset of Adenocarcinoma in a Child with Fa...Familial adenomatous polyposis is an inh...
- Inactivation of the APC Gene is Constant in Adrenocortical Tumors from Patients with Familial Adenomatous Polyposis ...PURPOSE : In adrenocortical tumors (ACT)...
- Familial Syndromic Papillary Thyroid Carcinoma Report of Two CasesAIM : to describe two cases of familial ...
- Complete Rectosigmoid Prolapse in a Patient with Familial Adenomatous PolyposisColonoscopy in a 23-year-old woman to ev...
- Mutational Analysis of the APC Gene in Cribriform-Morula Variant of Papillary Thyroid CarcinomaINTRODUCTION : Familial adenomatous poly...