welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Rectal Epithelial Apoptosis in Familial Adenomatous Polyposis Patients Treated with Sulindac
source: Gut Journal
year: 1999
authors: Keller J J, Offerhaus G J, Polak M, Goodman S N, Zahurak M L, Hylind L M, Hamilton S R, Giardiello F M
summary/abstract:BACKGROUND : Sulindac regresses colorectal adenomas in patients with familial adenomatous polyposis (FAP), although the mechanism of polyp regression is unclear.
AIMS : To determine whether differences occur in alteration of rectal epithelial apoptotic index and expression of apoptosis related proteins in FAP patients treated with sulindac compared with placebo.
PATIENTS : Twenty one FAP patients; 12 had not undergone colectomy.
METHODS : Patients with FAP were treated with sulindac 150 mg orally twice a day for three months (n=10) or placebo (n=11). Colorectal polyp number was determined and biopsies of the normal rectal mucosa were performed before and after three months of treatment. Response to treatment and alteration of the apoptotic ratio (index in base of crypt divided by index in surface epithelium) were evaluated. Bcl-2, bax, p21/WAF-1, and p53 proteins were assessed semiquantitatively by immunohistochemistry.
RESULTS : Significant decreases in polyp number and in the apoptotic ratio were seen in patients treated with sulindac compared with controls. The mean percentage change in polyp number from baseline was -46% in the sulindac group and +13% in the placebo group (p=0.005). Mean percentage change in the apoptotic ratio was -8% and +25% in the sulindac and placebo treated patients, respectively (p=0.004). No differences in expression or compartmentalisation of apoptosis related proteins were noted between treatment groups.
CONCLUSIONS : Sulindac regression of colorectal adenomas is accompanied by alteration of the rectal epithelial apoptotic ratio with relative increase in apoptosis in surface cells compared with the deeper crypt. The utility of the apoptotic ratio as an intermediate biomarker for colorectal tumorigenesis deserves further study.
organization: Netherlands Academic Medical Centreread more full text source
expertly curated content related to this topic
-
Eicosapentaenoic Acid Reduces Rectal Polyp Number and Size in Familial Adenomatous PolyposisOBJECTIVE : The omega-3 polyunsaturated ...
-
Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)The purpose of this randomized, double-b...
-
Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous Polypos...This randomized phase II trial studies h...
-
Diagnosis, Surveillance, and Treatment Strategies For Familial Adenomatous Polyposis: Rationale and UpdateFamilial adenomatous polyposis is charac...
-
Food Fit for a Baby J-pouch: The Early Post-Proctocolectomy Diet (the newest fad diet)https://www.youtube.com/watch?v=ms8o1BBN...
-
Familial Adenomatous PolyposisFamilial adenomatous polyposis is an inh...
-
Teamwork Makes a Life-Changing Difference for Luishttps://www.youtube.com/watch?v=bpnoHHL0...