welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Risk of Ileal Pouch Neoplasms in Patients With Familial Adenomatous Polyposis
source: World journal of gastroenterology
year: 2013
authors: Tajika M, Niwa Y, Bhatia V, Tanaka T, Ishihara M, Yamao K
summary/abstract:Restorative proctocolectomy is the most common surgical option for patients with familial adenomatous polyposis (FAP). However, adenomas may develop in the ileal pouch mucosa over time, and even carcinoma in the pouch has been reported. We therefore reviewed the prevalence, nature, and treatment of adenomas and carcinoma that develop after proctocolectomy in the ileal pouch mucosa in patients with FAP. In 25 reports that were reviewed, the incidence of adenomas in the ileal pouch varied from 6.7% to 73.9%. Several potential factors that favor the development of pouch polyposis have been investigated, but many remain controversial. Nevertheless, it seems certain that the age of the pouch is important. The risk appears to be 7% to 16% after 5 years, 35% to 42% after 10 years, and 75% after 15 years. On the other hand, only 21 cases of ileal pouch carcinoma have been recorded in the literature to date. The diagnosis of pouch carcinoma was made between 3 to 20 years (median, 10 years) after pouch construction. Although the risk of malignant transformation in ileal pouches is probably low, it is not negligible, and the long-term risk cannot presently be well quantified. Regular endoscopic surveillance, especially using chromoendoscopy, is recommended.
organization: Aichi Cancer Center HospitalDOI: 10.3748/wjg.v19.i40.6774
read more full text source
expertly curated content related to this topic
-
Bonnie June 2008https://jtvcancersupport.com/embed/55453...
-
Summertime and FAP – An Interview with Tracy WhittI was lucky enough to spend a littleĀ ti...
-
Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis in ChildrenPURPOSE : This study was designed to eva...
-
Restorative Proctectomy with Ileal Pouch-Anal Anastomosis in Obese PatientsPURPOSE : The aim of this study was to a...
-
Psychosocial Issues in Genetic Testing for Familial Adenomatous Polyposis: a Review of the LiteratureOBJECTIVES: Familial adenomatous polypos...
-
Perspectives on Marriage with Chronically Ill ChildrenMarriage is already a complicated and of...
-
Desmoid Clinical Trial Update & Stuff!https://www.youtube.com/watch?v=uaMKoMHE...