welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Risk of Ileal Pouch Neoplasms in Patients With Familial Adenomatous Polyposis
source: World journal of gastroenterology
year: 2013
authors: Tajika M, Niwa Y, Bhatia V, Tanaka T, Ishihara M, Yamao K
summary/abstract:Restorative proctocolectomy is the most common surgical option for patients with familial adenomatous polyposis (FAP). However, adenomas may develop in the ileal pouch mucosa over time, and even carcinoma in the pouch has been reported. We therefore reviewed the prevalence, nature, and treatment of adenomas and carcinoma that develop after proctocolectomy in the ileal pouch mucosa in patients with FAP. In 25 reports that were reviewed, the incidence of adenomas in the ileal pouch varied from 6.7% to 73.9%. Several potential factors that favor the development of pouch polyposis have been investigated, but many remain controversial. Nevertheless, it seems certain that the age of the pouch is important. The risk appears to be 7% to 16% after 5 years, 35% to 42% after 10 years, and 75% after 15 years. On the other hand, only 21 cases of ileal pouch carcinoma have been recorded in the literature to date. The diagnosis of pouch carcinoma was made between 3 to 20 years (median, 10 years) after pouch construction. Although the risk of malignant transformation in ileal pouches is probably low, it is not negligible, and the long-term risk cannot presently be well quantified. Regular endoscopic surveillance, especially using chromoendoscopy, is recommended.
organization: Aichi Cancer Center HospitalDOI: 10.3748/wjg.v19.i40.6774
read more full text source
expertly curated content related to this topic
-
survivor story: dave brusieI graduated from high school in 1975 and...
-
Sex and the Male Ostomate Fact SheetMany sex problems that male ostomates ex...
-
Good Bye ColonHi there and welcome to Good Bye Colon. ...
-
Shrinking the silenceI’ve been thinking about starting a bl...
-
Ileoanal Pouch Dysfunction and the Use of a Medena Catheter Following Hospital DischargeWith the advent of new surgical techniqu...
-
diane’s storyI was devastated, I had made all my arra...
-
lorraine’s storyLorraine’s perspective on Familial Ade...