welcome to oneFAPvoice- a positively charged Familial Adenomatous Polyposis community.
- join today!
Rofecoxib Reduces Polyp Recurrence in Familial Polyposis.
source: Digestive diseases and sciences
authors: Hallak A, Alon-Baron L, Shamir R, Moshkowitz M, Brazowski E, Halpern Z, Bulvik B, Arber Nsummary/abstract:
The long-term (mean of 16.4 +/- 4.2 months) efficacy and safety of rofecoxib (a specific COX-2 inhibitor) in maintaining the colon free of polyps in familial polyposis patients was assessed. Eight patients were treated with rofecoxib 25 mg every day. Sigmoidoscopy/colonoscopy was performed at study entry and every six months. At each endoscopy the number, size, and histological grade of all polyps were assessed, and the polyps were removed. The drug was well tolerated with no significant adverse events throughout the study. A highly significant reduction in the rate of polyp formation (70-100%) was observed in all patients from a mean number of 15.1 +/- 11.7 at baseline to 6.0 +/- 5.8 at one year and 1.6 +/- 1.6 at the end of follow-up (P = 0.016 and 0.008, respectively). No patient developed cancer or high-grade adenoma. In conclusion, Long-term use of rofecoxib is well tolerated and effective in inhibiting polyp formation in polyposis patients.organization: Tel Aviv Sourasky Medical Center
expertly curated content related to this topic
Minimal Access Laparoscopic Surgery for Treatment of Ulcerative Colitis and Familial Adenomatous Polyposis Coli in C...BACKGROUND : Laparoscopic restorative pr...
The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized C...Familial adenomatous polyposis (FAP) lea...
Long-Term Outcome of Sporadic and FAP-Associated Desmoid Tumors Treated with High-Dose Selective Estrogen Receptor M...Aim of this study is to evaluate the out...
Body Image, Cosmesis, Quality of Life, and Functional Outcome of Hand-Assisted Laparoscopic Versus Open Restorative ...BACKGROUND : This study aimed to compare...
Global Quantitative Assessment of the Colorectal Polyp Burden in Familial Adenomatous Polyposis by Using a Web-based...BACKGROUND: Accurate measures of the to...
Desmoid Update – NIH clinical trial!https://www.youtube.com/watch?v=OE_GSI8A...
Ileal Pouch Anal Anastomosis: Analysis of Outcome and Quality of Life in 3707 PatientsBACKGROUND : Ileal pouch anal anastomosi...