welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Rofecoxib Reduces Polyp Recurrence in Familial Polyposis.
source: Digestive diseases and sciences
year: 2003
authors: Hallak A, Alon-Baron L, Shamir R, Moshkowitz M, Brazowski E, Halpern Z, Bulvik B, Arber N
summary/abstract:The long-term (mean of 16.4 +/- 4.2 months) efficacy and safety of rofecoxib (a specific COX-2 inhibitor) in maintaining the colon free of polyps in familial polyposis patients was assessed. Eight patients were treated with rofecoxib 25 mg every day. Sigmoidoscopy/colonoscopy was performed at study entry and every six months. At each endoscopy the number, size, and histological grade of all polyps were assessed, and the polyps were removed. The drug was well tolerated with no significant adverse events throughout the study. A highly significant reduction in the rate of polyp formation (70-100%) was observed in all patients from a mean number of 15.1 +/- 11.7 at baseline to 6.0 +/- 5.8 at one year and 1.6 +/- 1.6 at the end of follow-up (P = 0.016 and 0.008, respectively). No patient developed cancer or high-grade adenoma. In conclusion, Long-term use of rofecoxib is well tolerated and effective in inhibiting polyp formation in polyposis patients.
organization: Tel Aviv Sourasky Medical Centerread more
expertly curated content related to this topic
- A Randomized, Double-Blind, Placebo-Controlled Trial of the Effects of Rofecoxib, a Selective Cyclooxygenase-2 Inhib...PURPOSE : The aim of this study was to e...
- Cell Proliferation and Apoptotic Indices Predict Adenoma Regression in a Placebo-Controlled Trial of Celecoxib in Fa...BACKGROUND : Celecoxib was shown to regr...
- Successful Treatment of Ileal Pouch Desmoids using Multimodal Chemotherapy with Low-Dose Vinblastine and Methotrexat...We describe a case of multiple desmoid t...
- Carcinoma Colon and Managementhttp://www.slideshare.net/shivkishor/car...
- Frank A. Sinicrope, MDInterests: Colorectal cancer prevention...
- Colorectal Polyps in ChildhoodPURPOSE OF REVIEW: Colorectal polyps ar...