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Role of Surgery in Familial Adenomatous Polyposis and Hereditary Non Polyposis Colorectal Cancer (Lynch Syndrome)
source: Surgical oncology clinics of North America
year: 2009
authors: Kerrington D. Smith, Miguel A. Rodriguez-Bigas
summary/abstract:Surgery remains the mainstay of treatment for patients who develop colorectal cancer (CRC) in the setting of a hereditary CRC syndrome. In patients with a hereditary CRC syndrome, surgery can be prophylactic, therapeutic with curative intent, and, in some cases, palliative. The type and extent of surgical resection in familial adenomatous polyposis (FAP) and in the Lynch syndrome is influenced by differences in the natural history of carcinogenesis between the two syndromes and by the effectiveness of and patient compliance with available surveillance strategies. In this article, the surgical options for the management of patients with FAP and Lynch syndrome are discussed.
organisation: Dartmouth-Hitchcock Medical CenterDOI: 10.1016/j.soc.2009.07.006
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