welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Severe Duodenal Involvement in Familial Adenomatous Polyposis Treated by Pylorus-Preserving Pancreaticoduodenectomy
source: Annals of surgical oncology
year: 2012
authors: Frédéric Caillié, François Paye, Benoit Desaint, Malika Bennis, Yann Parc, Magali Svrcek, Jérémie H. Lefèvre, Pierre Balladur
summary/abstract:PURPOSE : Pancreaticoduodenectomy is an alternative to pancreas-sparing duodenectomy for radical treatment of duodenal lesions. The aims of this study were to assess the results of pylorus-preserving pancreaticoduodenectomy (PPPD) for severe duodenal polyposis in familial adenomatous polyposis in terms of morbidity, long-term influence on functional results, the recurrence rate of cancer or jejunal polyps, and survival.
METHODS : All patients operated on for a PPPD between 1992 and 2009 were included. Clinical data, endoscopic findings, and pathologic examinations were evaluated.
RESULTS : A total of 19 patients underwent PPPD for severe duodenal polyposis (17 Spigelman IV, 1 Spigelman III, and 1 invasive carcinoma). Postoperative mortality was nil. The postoperative morbidity rate was 42%, including 4 pancreatic fistulae (21%) and 2 delayed gastric emptying (11%). Pathologic examination found 7 invasive carcinomas, of which only 1 was known before resection. One third of patients operated on without a preoperative diagnosis of malignancy already had an invasive duodenal carcinoma. After a mean follow-up of 58 months, 16 patients were alive. Thirteen patients underwent endoscopic follow-up, and new adenomas were found in 4 (31%). All were treated successfully during the same endoscopic procedure. PPPD did not modify the functional result after coloproctectomy.
CONCLUSIONS : PPPD remains a safe and efficient therapeutic option for severe duodenal polyposis in familial adenomatous polyposis patients.
organization: Hôpital Saint AntoineDOI: 10.1245/s10434-012-2221-x
read more full text source
expertly curated content related to this topic
- Psychosocial Issues in Genetic Testing for Familial Adenomatous Polyposis: a Review of the LiteratureOBJECTIVES: Familial adenomatous polypos...
- Role of Ileostomy in Restorative ProctocolectomyRestorative proctocolectomy (RP) is the ...
- Familial Adenomatous Polyposis-Associated Papillary Thyroid CancerPapillary thyroid carcinoma (PTC) associ...
- The J-Pouch Group Dietary GuidelinesGood nutrition plays an essential role i...
- Sex and the Female Ostomate Fact SheetAfter surgery, while you are recovering ...
- Surgical Management of the Duodenal Manifestations of Familial Adenomatous PolyposisBACKGROUND: Duodenal adenomas develop i...
- Rectal Proliferation and Polyp Occurrence in Pateints with Familial Adenomatous Polyposis after Sulindac TreatmentBACKGROUND/AIMS : Sulindac, a nonsteroid...