welcome to oneFAPvoice- a positively charged Familial Adenomatous Polyposis community.
- join today!
Significantly Increased Pregnancy Rates After Laparoscopic Restorative Proctocolectomy: A Cross-sectional Study
source: Annals of surgery
authors: Bartels S A, DʼHoore A, Cuesta M A, Bensdorp A J, Lucas C, Bemelman W Asummary/abstract:
To assess the impact of a laparoscopic approach on female fecundity in ileoanal pouch surgery.
Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is associated with tubal factor infertility in female patients. Different studies showed less adhesion formation after laparoscopic colectomy. The relation between laparoscopic pouch surgery and fertility, however, has not been studied so far.
This cross-sectional study was carried out in 3 university hospitals in the Netherlands and in Belgium. Female patients older than 18 years that had IPAA under the age of 41 were eligible for inclusion (n = 179). We sent them a questionnaire addressing medical and fertility history. The primary endpoint was time to first spontaneous pregnancy after IPAA. This study has been registered with ISRCTN.org (ISRCTN85421386).
Of 179 eligible patients, 160 (89%) returned the questionnaire. After IPAA, 50 (31%) patients attempted to conceive. Of these, 23 (46%) had undergone open and 27 (54%) had undergone laparoscopic IPAA. Patient characteristics were similar in both groups. Indications for surgery were ulcerative colitis (UC) in 37 patients, familial adenomatous polyposis (FAP) in 12 patients, and colonic ischemia in 1 patient. A Kaplan-Meier survival function was plotted for time to first spontaneous pregnancy and showed a higher pregnancy rate after laparoscopic IPAA (log-rank, P = 0.023). Similarly, subsequent survival analysis for all patients with UC showed an increased pregnancy rate for the laparoscopic group (log-rank, P = 0.033).
Pregnancy rates are significantly higher after laparoscopic IPAA. This makes the laparoscopic approach the method of choice in young women.
read more full text source
expertly curated content related to this topic
Long Term Treatment with Sulindac in Familial Adenomatous Polyposis: Is there an Actual Efficiacy in Prevention of ...BACKGROUND AND OBJECTIVES : Ileorectal a...
A Total Laparoscopic Approach Reduces the Infertility Rate after Ileal Pouch-Anal Anastomosis: A 2-Center StudyOBJECTIVE: To assess the infertility ra...
Restorative Proctectomy with Ileal Pouch-Anal Anastomosis in Obese PatientsPURPOSE : The aim of this study was to a...
Surgical Prophylaxis in Familial Adenomatous Polyposis: Do Pre-Existing Desmoids Outside the Abdominal Cavity Matter...Desmoid tumours (DT) are myofibroblastic...
Mow down Gardner SyndromeGardner Syndrome (GS) is a rare disease....
Risk-Reducing Surgery in FAP: Role for Surgeons Beyond the IncisionBACKGROUND : Although primary therapy in...
f.a.p (familial adenomatous polyposis)FAP is a disease that affects mostly the...