welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Surveillance of Duodenal Adenomas in Familial Adenomatous Polyposis Reveals High Cumulative Risk of Advanced Disease
source: Journal of clinical oncology
year: 2004
authors: Jean-Christophe Saurin, Christelle Gutknecht, Bertrand Napoleon, Annick Chavaillon, Jean-Yves Scoazec, Thierry Ponchon, René Ecochard, Jean-Alain Chayvialle
summary/abstract:PURPOSE : The development of high-grade dysplasia (HGD) on duodenal or jejunal adenomas and of late-stage (stage IV) duodenal polyposis are major clinical events for familial adenomatous polyposis (FAP) patients. Our aim was to determine their respective frequency, risk factors, and cumulative risk.
PATIENTS AND METHODS : A prospective, optimized, endoscopic surveillance protocol was applied to 58 FAP patients in a university hospital. The number, size, and histology of duodenojejunal polyps were assessed, and the Spigelman’s score was calculated at each endoscopy. Cox regression and linear regression analysis were used to determine risk factors for HGD development and the cumulative risk of stage IV duodenal polyposis, respectively.
RESULTS : During a median (+/- standard deviation) follow-up of 47.9 +/- 15.6 months, 35 patients with at least two consecutive examinations had 107 duodenojejunal examinations. The Spigelman’s score increased in 21 patients (60.0%), and HGD developed in 12 patients (34.2%). High initial Spigelman’s score (> 7 points), but not age or APC mutation site, was a risk factor for HGD development. Estimated cumulative risk of developing stage IV duodenal polyposis was of 42.9% at age 60 (95% CI, 35.7% to 50.0%) and 50.0% at age 70 (95% CI, 42.9% to 57.1%).
CONCLUSION : This prospective series shows a higher duodenal polyposis progression rate and cumulative risk of late-stage (stage IV) duodenal polyposis in FAP patients compared with previous series. These results suggest that current modalities for surveillance and management of these patients need revision.
organization: Hôpital Edouard Herriotread more full text source
expertly curated content related to this topic
-
Familial Adenomatous Polyposis (FAP)https://www.youtube.com/watch?v=kWx6aT-f...
-
Familial Polyposis Coli (Familial Adenomatous Polyposis or FAP)Colonic polyps are common especially in ...
-
How often should patients with familial colorectal cancer risk be screened?Medical Research: What is the background...
-
MUTYH Associated PolyposisThis summery provides diagnosis criteri...
-
What is life’s a polyp?https://www.youtube.com/watch?v=NDAmcswf...
-
Evaluation of Guidelines for Management of Familial Adenomatous Polyposis in a Multicenter Pediatric CohortOBJECTIVE: To retrospectively assess, i...
-
Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal ScreeningColorectal cancer (CRC) is the fourth mo...