welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Surveillance of Duodenal Adenomas in Familial Adenomatous Polyposis Reveals High Cumulative Risk of Advanced Disease
source: Journal of clinical oncology
year: 2004
authors: Jean-Christophe Saurin, Christelle Gutknecht, Bertrand Napoleon, Annick Chavaillon, Jean-Yves Scoazec, Thierry Ponchon, René Ecochard, Jean-Alain Chayvialle
summary/abstract:PURPOSE : The development of high-grade dysplasia (HGD) on duodenal or jejunal adenomas and of late-stage (stage IV) duodenal polyposis are major clinical events for familial adenomatous polyposis (FAP) patients. Our aim was to determine their respective frequency, risk factors, and cumulative risk.
PATIENTS AND METHODS : A prospective, optimized, endoscopic surveillance protocol was applied to 58 FAP patients in a university hospital. The number, size, and histology of duodenojejunal polyps were assessed, and the Spigelman’s score was calculated at each endoscopy. Cox regression and linear regression analysis were used to determine risk factors for HGD development and the cumulative risk of stage IV duodenal polyposis, respectively.
RESULTS : During a median (+/- standard deviation) follow-up of 47.9 +/- 15.6 months, 35 patients with at least two consecutive examinations had 107 duodenojejunal examinations. The Spigelman’s score increased in 21 patients (60.0%), and HGD developed in 12 patients (34.2%). High initial Spigelman’s score (> 7 points), but not age or APC mutation site, was a risk factor for HGD development. Estimated cumulative risk of developing stage IV duodenal polyposis was of 42.9% at age 60 (95% CI, 35.7% to 50.0%) and 50.0% at age 70 (95% CI, 42.9% to 57.1%).
CONCLUSION : This prospective series shows a higher duodenal polyposis progression rate and cumulative risk of late-stage (stage IV) duodenal polyposis in FAP patients compared with previous series. These results suggest that current modalities for surveillance and management of these patients need revision.
organization: Hôpital Edouard Herriotread more full text source
expertly curated content related to this topic
-
What is life’s a polyp?https://www.youtube.com/watch?v=NDAmcswf...
-
Guidelines For the Management of Colorectal CancerColorectal cancer in the United Kingdom ...
-
Find Care for Familial Adenomatous Polyposis at Northwell HealthFamilial adenomatous polyposis (FAP) is ...
-
Hello FAPulous People!https://youtu.be/odS-KqgbPLw...
-
For the (Medical) Record: What I Wished My Doctors Knew About Familial Adenomatous PolyposisOver the years, you’ve been judiciousl...
-
Cribriform-Morular Variant of Papillary Thyroid Carcinoma: Clue to Early Detection of Familial Adenomatous Polyposis...The cribriform-morular variant (CMV) of ...
-
Progression to Advanced Neoplasia is Infrequent in Post Colectomy Familial Adenomatous Polyposis Patients Under Endo...BACKGROUND AND STUDY AIMS : Advanced neo...