welcome to oneFAPvoice- a positively charged Familial Adenomatous Polyposis community.
- join today!
The Pathology of Hereditary Polyposis Syndromes
authors: Novelli Msummary/abstract:
Our understanding of the genetics and pathology of familial colorectal cancer continues to evolve with both the discovery of underlying genetic defects and the description of entirely new entities. Genetic analysis has demonstrated phenotypic overlap between some of these syndromes, such that their nosology is rapidly becoming based on genetics with clinicopathological features playing a secondary, but important, role. Further clinical characterization of these syndromes has also demonstrated widely differing risks for the development of colorectal cancer and a range of other malignancies with implications for both the affected patient and members of their families. This review aims to outline the clinical, pathological and genetic features of this increasingly complex group of diseases.organization: UCLH NHS Foundation Trust
read more full text source
expertly curated content related to this topic
Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors̵...Colorectal cancer (CRC) is a leading cau...
Familial Adenomatous PolyposisFamilial adenomatous polyposis (FAP) is ...
Mutation Analysis of the APC Gene in Unrelated Korean Patients with FAP: Four Novel Mutations with Unusual PhenotypeGermline mutations within the adenomatou...
Functional Analysis of MUTYH Mutated Proteins Associated with Familial Adenomatous PolyposisThe MUTYH DNA glycosylase specifically r...
How MicroRNAs Influence Both Hereditary and Inflammatory-Mediated Colon CancersMicroRNAs have emerged as important post...
Location in the Large Bowel Influences the APC Mutations Observed in FAP AdenomasThe right colon differs from the left, i...
Defining the Overlap between Sporadic and Attenuated Familial Adenoma RiskPoster Presentation Background: Muta...