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The Role of High-resolution Endoscopy and Narrow-Band Imaging in the Evaluation of Upper GI Neoplasia in Familial Adenomatous Polyposis
source: Gastrointestinal Endoscopy
year: 2013
authors: Lopez-Ceron M, van den Broek F J, Mathus-Vliegen E M, Boparai K S, van Eeden S, Fockens P, Dekker E
summary/abstract:BACKGROUND:
The Spigelman classification stratifies cancer risk in familial adenomatous polyposis (FAP) patients with duodenal adenomatosis. High-resolution endoscopy (HRE) and narrow-band imaging (NBI) may identify lesions at high risk.
OBJECTIVE:
To compare HRE and NBI for the detection of duodenal and gastric polyps and to characterize duodenal adenomas harboring advanced histology with HRE and NBI.
DESIGN:
Prospective, nonrandomized, comparative study. Retrospective image evaluation study.
SETTING:
Tertiary-care center.
PATIENTS:
Thirty-seven FAP patients undergoing surveillance upper endoscopies.
INTERVENTION:
HRE endoscopy was followed by NBI. The number of gastric polyps and Spigelman staging were compared. Duodenal polyp images were systematically reviewed in a learning and validation phase.
MAIN OUTCOME MEASUREMENTS:
Number of gastric and duodenal polyps detected by HRE and NBI and prevalence of specific endoscopic features in duodenal adenomas with advanced histology.
RESULTS:
NBI did not identify additional gastric polyps but detected more duodenal adenomas in 16 examinations, resulting in upgrades of the Spigelman stage in 2 cases (4.4%). Pictures of 168 duodenal adenomas (44% advanced histology) were assessed. In the learning phase, 3 endoscopic features were associated with advanced histology: white color, enlarged villi, and size ≥1 cm. Only size ≥1 cm was confirmed in the validation phase (odds ratio 3.0; 95% confidence interval, 1.2-7.4).
LIMITATIONS:
Nonrandomized study, scant number of high-grade dysplasia adenomas.
CONCLUSION:
Inspection with NBI did not lead to a clinically relevant upgrade in the Spigelman classification and did not improve the detection of gastric polyps in comparison with HRE. The only endoscopic feature that predicted advanced histology of a duodenal adenoma was size ≥1 cm.
DOI: 10.1016/j.gie.2012.11.033
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