welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Thyroid Carcinoma in Patients with Familial Adenomatous Polyposis
source: Asian journal of surgery
year: 2003
authors: Rohaizak M, Jasmi A Y, Ismail M A, Munchar M J, Meah F A
summary/abstract:There has been a growing awareness of the association between papillary thyroid carcinoma and familial adenomatous polyposis (FAP). The cases of four young patients with papillary thyroid carcinoma occurring with FAP are presented. Three patients underwent surgery to provide specimens for detailed histological examination. The surgical specimens showed well-encapsulated multicentric tumours exhibiting a predominantly papillary architectural growth pattern. In some areas, follicular architecture and cribriform patterns were noted. Atypical areas of spindle cells in a trabecular or solid configuration, which are not normally seen in classical papillary thyroid carcinoma, were evident. Malignant cells exhibited a graduation of cuboidal to tall cells with abundant amphophilic cytoplasm. The nuclei did not exhibit the typical nuclear clearing as seen in papillary thyroid carcinoma, but nuclear grooving and inclusions were noted. Psammoma bodies were not seen in any of the specimens. In a limited review of these patients, features such as young age at presentation, multicentricity and unusual histology suggest that thyroid carcinoma associated with FAP may represent a distinct form of thyroid cancer.
organization: Hospital Universiti Kebangsaan Malaysiaread more full text source
expertly curated content related to this topic
- Clinical Practice Guidelines for Surveillance Colonoscopy – in Adenoma Follow-up; Following Curative Resection of ...SUMMARY OF CLINICAL PRACTICE RECOMMENDAT...
- Multiple Neoplasia in a 15-Year-Old Girl with Familial Adenomatous PolyposisA 15-year-old girl with adenomatous poly...
- Doctors were Startled to Find the Cause of this 24-year-old’s Excruciating PainEach time it happened, Johanna Dickson t...
- 23-year-old Mount Airy woman to spend lifetime with cancerAn incurable cancer has touched every pa...
- Therapeutic Approaches for Patients with Coexisting Familial Adenomatous Polyposis and Colorectal CancerColorectal cancer is a major cause of de...
- Thyroid Cancer and Benign Thyroid Disease in Patients with Familial Adenomatous Polyposis (FAP): Memorial Sloan-Kett...Poster PresentationBackground: Pati...
- Different Phenotype Manifestation of Familial Adenomatous Polyposis in Families with APC Mutation at Codon 1309Germline mutation in APC gene induced de...