welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Understanding Phenotypic Variation in Rodent Models With Germline APC Mutations
source: Cancer research
year: 2013
authors: Zeineldin M, Neufeld K L
summary/abstract:Adenomatous polyposis coli (APC) is best known for its crucial role in colorectal cancer suppression. Rodent models with various Apc mutations have enabled experimental validation of different Apc functions in tumors and normal tissues. Since the development of the first mouse model with a germline Apc mutation in the early 1990s, 20 other Apc mouse and rat models have been generated. This article compares and contrasts currently available Apc rodent models with particular emphasis on providing potential explanations for their reported variation in three areas: (i) intestinal polyp multiplicity, (ii) intestinal polyp distribution, and (iii) extraintestinal phenotypes.
organization: University of KansasDOI: 10.1158/0008-5472.CAN-12-4607
read more full text source
expertly curated content related to this topic
-
Different Phenotype Manifestation of Familial Adenomatous Polyposis in Families with APC Mutation at Codon 1309Germline mutation in APC gene induced de...
-
Genomics of Hereditary Colorectal Cancer: Lessons Learnt from 25 Years of the Singapore Polyposis RegistryINTRODUCTION : The Singapore Polyposis R...
-
Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors̵...Colorectal cancer (CRC) is a leading cau...
-
Pathways of Colorectal CarcinogenesisThis review of the molecular and cellula...
-
A Large-scale Meta-analysis to Refine Colorectal Cancer Risk Estimates Associated with MutYH VariantsBACKGROUND: defective DNA repair has a ...
-
Education and Management of Patients with Familial Adenomatous Polyposis. Are We Making Progress? A Case ReportAbstract: A 25-year-old male patient was...