welcome to oneFAPvoice
- a positively charged Familial Adenomatous Polyposis community.- join today!
- login
Understanding Phenotypic Variation in Rodent Models With Germline APC Mutations
source: Cancer research
year: 2013
authors: Zeineldin M, Neufeld K L
summary/abstract:Adenomatous polyposis coli (APC) is best known for its crucial role in colorectal cancer suppression. Rodent models with various Apc mutations have enabled experimental validation of different Apc functions in tumors and normal tissues. Since the development of the first mouse model with a germline Apc mutation in the early 1990s, 20 other Apc mouse and rat models have been generated. This article compares and contrasts currently available Apc rodent models with particular emphasis on providing potential explanations for their reported variation in three areas: (i) intestinal polyp multiplicity, (ii) intestinal polyp distribution, and (iii) extraintestinal phenotypes.
organization: University of KansasDOI: 10.1158/0008-5472.CAN-12-4607
read more full text source
expertly curated content related to this topic
-
Germline and Somatic Mutations of the APC Gene in Papillary Thyroid Carcinoma Associated with Familial Adenomatous P...Patients with familial adenomatous polyp...
-
APC: The Key to Colon Cancer (The APC Protein and Its Role in Controlling the Cell Cycle)Poster Presentation Abstract: Colorec...
-
Multiple Desmoid Tumors in a Patient with Familial Adenomatous Polyposis caused by the Novel W421X MutationFamilial adenomatous polyposis (FAP) is ...
-
Guidelines for the Clinical Management of Familial Adenomatous Polyposis (FAP)Background: Familial adenomatous polypos...
-
Familial Risk-Colorectal Cancer: ESMO Clinical Practice GuidelinesLynch syndrome is the most common heredi...
-
Biallelic APC Inactivation was Responsible for Functional Adrenocortical Adenoma in Familial Adenomatous Polyposis w...Familial adenomatous polyposis (FAP) pat...
-
Broad Phenotypic Spectrum in Familial Adenomatous Polyposis; From Early Onset and Severe Phenotypes to Late Onset of...BACKGROUND : Familial adenomatous polypo...