Exclusive Interview with Chief Executive Officer and Chairman Jeffrey Jacob of Cancer Prevention Pharmaceuticals, Inc. live at the Bio CEO & Investor Conference.

Living with a rare genetic disease can be very difficult and challenging in terms of physical, emotional, and social being. People think they cannot survive with the disease and soon loose hope but somehow they do. This is just because of their strength that encourages them to fight back. In order to live a good life, find your inner strength and cope with the disease.

The idea for the #My31 Movement began as a realization by the founders of Hu-manity.co. People were creating tons of data, and were not able to control how it is used, manage it or be compensated for it. And yet, the data market is growing exponentially. This is the reason for the 31st Human Right: "Everyone has the right to legal ownership of their inherent human data as property."

Life's a Polyp explores daily life with chronic illness caused by two rare diseases - Familial Adenomatous Polyposis and Short Bowel Syndrome. Jenny, the blogger, is a FAP patient and was diagnosed with the disease when she was 8 years old. She had to undergo a colectomy to remove her colon because the colon cancer had started to develop. Since then, Jenny is suffering from various symptoms of FAP and coping up with the disease. Follow her video to know more about the life with a rare disease.

Short-bowel syndrome is a condition in which the small intestine is not able to function properly. It is generally accompanied by symptoms such as diarrhea, dehydration, malnutrition, etc. People suffering from this condition need to use the washroom many times a day. This may continue for several hours. In the following video, Jenny discusses what the day was like with Short Bowel Syndrome.

Jenny describes different coping techniques for managing bothersome emotions, sleep, and pain after a recent medical procedure. These techniques have helped her cope with the symptoms in high school. Follow the video to know more about these techniques and follow them to cope up with your symptoms.

Jenny is a FAP patient. From past few months, she is experiencing an increase in the severity of symptoms such as nausea, abdominal pain, vomiting, etc. Upon proper diagnosis, her doctor told her that she is suffering from C diff infection. C diff is referred to a bacterial strain called clostridium difficile which results in the occurrence of diarrhea and more serious intestinal conditions like colitis.

Ostomy is a surgical procedure in which a hole is made in the abdomen wall in order to excrete the waste out of the body. This procedure is generally performed when the patient is suffering from some serious intestinal condition. A pouch like bag is placed on the ostomy. The body excretes out its waste in the bag. As soon as the bag is full, it has to be removed properly and discarded. This video is a guide on how to wear your ostomy and clean it properly.

Familial adenomatous polyposis (FAP) is an inherited disease in which numerous growths, called polyps are observed in the colon and rectum . Almost all patients with this condition have to get their colon removed. Iron deficiency anemia is the most common symptom observed in FAP patients. This symptom occurs due to frequent blood loss from the body because of colon cancer. To properly treat the condition, patients have to undergo iron infusion sessions regularly for maintaining iron levels in the blood.  

Familial adenomatous polyposis (FAP) is an inherited disease which is characterized by occurrence of intestinal cancer. In this condition, multiple growths, called polyps are observed in the colon and rectum part of intestine. Ostomy is a surgical procedure in which a separate opening, also known as stoma, is created near the abdomen in the body for waste to excrete out of the body. A bag is then attached to stoma where the waste could be collected. There are various types of ostomy. Learn about different types of ostomies and bowel and bladder diversions in the video.

Cole Eicher is 13 years old and he is a brain cancer survivor. For Cole, living a life with brain cancer was very difficult. He went through surgeries and various chemotherapy sessions to treat his cancer. Today, he is a cancer survivor and helps the organization in spreading awareness against cancer and raise funds in order to support research. The video gives an insight of the life of Cole Eicher and his contributions to the society.

Micheal Jimenez describes his battle with Familial Adenomatous Polyposis.

This video was filmed a year ago (I'm missing the blonde hair now that I see it again) and I have no idea why I never posted it but, I just rediscovered it and think it's still relevant for those considering or recovering from these surgeries. It looks like there are one or two other videos I made ages ago that escaped posting so hopefully I'll get them up in the near future! For those of you who are overcoming weight loss issues after these surgeries, I highly recommend Ben&Jerry's or a trip to S.E. Asia as I'm pretty sure that's how I gained my pre-surgery weight back (OK, let's be serious, I'd recommend these things to everyone regardless of their surgical history!)!

Hey! I am sorry it's been so long since my last video but, I've gotten so wrapped up in the craziness and excitement of traveling that I've neglected this channel a bit. So, I wanted to channel some of my travel enthusiasm into another video about my experience traveling with a j-pouch. I've learned a few new things since my first experience being colonless and abroad which I talk about in this video! Also, I need your help! I would like to make a collective map detailing where j-pouchers and ostomates have traveled to demonstrate that having an abbreviated digestive tract doesn't translate to abbreviated adventures. Please comment below or message me with foreign places you've explored with your j-pouch or ostomy even if it was an hour away from your home! Vacation season is approaching so let's show other j-pouchers and ostomates that they can still take an exotic holiday trip!

In this video, I briefly list the F.A.P. screening tests that I have and will periodically undergo to monitor the extra-colonic areas that can be affected by this disease. If you have any suggestions about changes I should make to my screening process, please let me know as this is new territory for me and a lot of the doctors I am interacting with!

On July 5th, 2011, I was diagnosed with Familial Adenomatous Polyposis. As the one year anniversary of my diagnosis just passed, I thought I would share with you the process of how I was diagnosed as a person with a de novo mutation. Diagnosing F.A.P. early on is crucial since it's most fatal aspect (colorectal cancer) tends to emerge at a very young age. I want to believe that sharing our diagnosis stories will help raise awareness about this disease and in doing so, might help those undiagnosed catch it sooner rather than later.

It is officially summer! Since for a lot of us that means it's bathing suit season, I thought I would hop into a bikini and show what my almost 7 month old j pouch formation scar looks like. As it is a keloid, I also talk about what keloids are and give you a tiny bit of backstory about its formation!

In this video, I talk about the preparation and experience involved in each of the F.A.P. screening tests that I just had done.

I wanted to make a video about F.A.P. and its effects on fertility. This is a sensitive issue for me but, as it is a component of F.A.P. (and one of the harder hitting ones for me), I thought it was necessary to address it. How you view and subsequently handle the issue of F.A.P. and fertility is up to you, your loved ones, and your doctors!

Desmoid tumors develop from fibroblasts which are found throughout the body. Desmoid tumors may become life threatening when they constrict vital organs such as kidneys, lungs or intestines. Some physicians consider desmoid tumors non-cancerous since they do not metastasize, but there is a danger of undertreating. Raphael Pollock, M.D., Ph.D., professor of Surgical Oncology at MD Anderson, explains this extremely rare cancer and its relationship to familial adenomatous polyposis (Gardner's Syndrome).

I recently traveled for the first time with my jpouch and wanted to share some things I learned from my experience! (part 2 of my Traveling with a Jpouch)

Anthony Holland: Associate Professor, Director of Music Technology, Skidmore College. DMA, MM, MM, BM; President: Novobiotronics Inc. [a nonprofit 501(c)(3) charitable and educational company]. Discovered the ability of Oscillating Pulsed Electric Fields (OPEF) to destroy cancer cells and MRSA in laboratory experiments. Expert in custom digital electronic signal design, synthesis and analysis for biological effects. Member: Bioelectromagnetics Society (BEMS), European Bioelectromagnetics Association (EBEA). Postdoctoral work: Center for Computer Research in Music and Acoustics (CCRMA) Stanford University. Advanced Digital Synthesis and Analysis studies with: Max Mathews (the ' Father of Computer Music'), John Chowning (founding Director of CCRMA, Electronic Composer and Inventor (famed FM Synthesis Patent); Jean-Claude Risset (Electronic Composer and founding Director of the Digital Synthesis Division of the internationally renowned IRCAM center, Paris, France); John Pierce: former Director of Sound Division: Bell Laboratories. In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)

A film by Miguel Silveira, Scott F Busch, & Ehsan Ghoreishi. First place winner at the Athens International Film + Video Festival for feature documentary (2014) Official selection at the Woodstock Film festival (2013)

Watch the video to know about FAP and its associated syndromes.

There are ileostomy options and an ileostomy reversal. This information is for people who need to undergo removal of their large intestine (colon) and rectum (proctocolectomy) -- usually for Ulcerative Colitis or Familial Adenomatous Polyposis. It is also for people who have already had surgery and are living with the type of ostomy called an ileostomy who are candidates for ileostomy reversal surgery. It is also for people with a malfunctioning Kock pouch or failed J-pouch.

The information is for people who need to undergo removal of their large intestine (colon) and rectum (proctocolectomy) -- usually for Ulcerative Colitis or Familial Adenomatous Polyposis. It is also for people who have already had surgery and are living with the type of ostomy called an ileostomy who are candidates for ileostomy reversal surgery. It is also for people with a malfunctioning Kock pouch or failed J-pouch. There is information about the different types of stomas and ostomy options, including dietary and stoma care concerns. Ulcerative Colitis surgery (removal of colon) is usually required when medical colitis treatment management fails or there is a risk of cancer. Colitis treatment fails in ulcerative colitis (sometimes called ulcerated colitis) in up to 50% of patients. This website is about avoiding a stoma or ostomy, or if you already have an ileostomy, this will give extensive information about ileostomy reversal.

The BCIR pouch is available for people with malfunctioning Kock Pouches or J-Pouches. The BCIR is located on the inside of the abdominal wall made from your small intestine. The pouch's function is to store intestinal waste, which is drained several times a day by inserting a catheter into a small opening in the abdomen called a stoma. The BCIR can be a life-changing option for patients who have had removal of their large intestine (colon and rectum) in that it creates a new pathway for the evacuation of waste. The BCIR is 100% internal, or intra-abdominal. It's also 100% appliance free.

The BCIR or Barnett Continent Intestinal Reservoir is the "Freedom Option" for patients with problems with a conventional (Brooke) ileostomy, failed ileo-anal J pouches, or Kock pouches, or those with ulcerative colitis or familial polyposis. The Barnett Continent Intestinal Reservoir (BCIR) offers you control over your situation.

October 6th, 2012 is World Ostomy Day! To celebrate, I decided to step out of my comfort zone and ask people some ostomy trivia questions! Hopefully this will help spark a conversation between ostomates and non-ostomates by providing non-ostomates with a basis to discuss ostomies while giving ostomates insight into common questions non-ostomates have concerning ostomies! Join in on the ostomy conversation and have a lovely World Ostomy Day!

This is a follow up video to "The Great Ostomy Conversation" where I answer some of the questions I asked and was asked while making the video.

"October 6th, 2012 was World Ostomy Day! To celebrate, I decided to step out of my comfort zone and ask people some ostomy trivia questions! Hopefully this will help spark a conversation between ostomates and non-ostomates by providing non-ostomates with a basis to discuss ostomies while giving ostomates insight into common questions non-ostomates have concerning ostomies! out "

Jenny is the blogger behind Life’s a Polyp, a blogspot blog that has become a guiding light for so many in the FAP and general rare disease community. In this video, Jenny briefly describes her experiences as an FAP patient, the changes that come along with accepting a chronic rare disease diagnosis like FAP, and the places that she turns to in order to find support, resources and guidance.

I know that I already posted a video about food but, what can I say, I'm food obsessed! In this video I talk about my diet immediately following both steps of my proctocolectomy including how my diet advanced in the first week of recovery and what solid foods I turned to during this period. Did you have a totally different experience? Eat different foods early on in your recovery? Crave Cheeze-Itz too? Let me know by commenting, sending a message, and/or subscribing

"To celebrate the one year anniversary of this channel (crazy how time flies!), I am holding the Toilet Bowl: Best and Worst Bathroom Contest! Here are the rules: 1. Submit up to two pictures of bathrooms, one for each category (one best bathroom pic and one worst). You may submit just one picture but you will of course have a greater chance of winning if you submit two! 2. Submit pictures by e-mailing them to FAPulousTV@gmail.com 3. Anyone can participate (you don't have to have F.A.P. or a jpouch) so spread the word about this contest to friends and family members who have seen some interesting toilets! 4. Once June 15th rolls around, check this channel's Facebook page (facebook.com/FAPulousTV) for the posted pictures and like the one picture you want to win. 5. The picture with the most ""likes"" at the end of the voting period will win the FAPulous prize package detailed in this video! Thanks you so much for checking out this channel and giving it reason to exist for a year! Now go take some cool pictures of bathrooms!"

One of the scariest things about someone removing a portion of your digestive tract is post-surgery diet restrictions. In this video I talk about how I have approached my post-proctocolectomy diet including any food restrictions I've encountered with the ostomy and j-pouch.

OK, I am far from the most stylish person out there but, after over a year of dealing with a protruding mass on my abdomen plus some time with an ostomy, I have garnered some fashion tips for concealing an abdominal mass. When I found out I was going to need a temporary ostomy, I instructed my mother to go out and buy me a new wardrobe as I feared my extensive clothes collection wasn't going to accommodate my new anatomy. I eventually discovered my fear was for naught and since then, I have wanted to make this video even though there are others out there on the subject (after all, it's a fashion video and we tend to put our own spin on style). Here I share some of my tried and true trendy tricks so you too can be a tumor trendsetter and/or ostomate original!

I recently traveled for the first time with my jpouch and wanted to share a few things I learned from my experience!

"I recently applied for and won a makeover organized by a wonderful person with a truly caring heart. The entire experience was phenomenal and was really momentous for me as I had wanted to change my look ever since undergoing the first colon-removing surgery. For all of you out there just about to undergo jpouch surgery, I think giving yourself a makeover in any sense of the word is a really good post-recovery goal. I feel that we do become a different person than who we were before our diagnosis and dealing with the disease can also make us feel not so glamorous at times so I like the idea of rewarding our struggles with a change in appearance! The experience also reminded me that phenomenal, caring, and generous people do exist even if we haven't met them yet and in the course of dealing with this disease, I think we can derive comfort by reminding ourselves of this fact (especially since we have to put up with a lot of inconsiderate, arrogant people in the medical and non-medical community)."

Hello! This is a video introducing this channel which will be dedicated to exploring what it's like living with Familial Adenomatous Polyposis (F.A.P.). Please subscribe and help raise awareness about this disease! Sound like a channel you'd like to contribute to? Have questions or video suggestions? Just want to say Hello? If so, feel free to message me or comment below!

"As of today, I have officially lived more than two years sans colon and I would love to be able to tell you that I am colonless and still going strong. Unfortunately, there has been an unwelcome new development in my F.A.P. experience in the form of a desmoid tumor which has complicated matters. In this Fast Announcement Post, I briefly discuss and show you my desmoid tumor in its current state as well as talk about the Toilet Bowl Contest which is still going on! Be sure to send pictures of your grossest and/or coolest bathroom encounters to FAPulousTV@gmail.com ! As this is my colonless anniversary, I also wanted to give a celebratory shout out to my colonless comrades for sporting a J or ; and so much more!"

Although there is no real consensus in the medical community (or rather, the members in it who have actually heard of desmoids) in regards to dealing with desmoid tumors, I tried to provide an overview of the options that are currently suggested. While there are treatment options out there that have had sporadic and varied definitions of success, there is no cure for desmoid tumors! Have a dear desmoid friend? Consider donating to the Desmoid Tumor Research Foundation (Side note and shameless plug: It's my birthday month and aiding in the destruction of these damn desmoids wouldn't be a bad gift...): http://www.dtrf.org

Let's play the word association game...I say chemo, you say...? Let me guess, hair loss? Certain types of chemo such as the one I'm on, can cause hair thinning which is a more gradual form of alopecia (hair loss) and I wanted to document what that process looks like five months into such a drug.

I haven't really mentioned clinical trials up until now and I think that's emblematic of the F.A.P. research landscape and the lack of F.A.P. geared studies. However, as I type, there's an F.A.P. clinical trial going on that's looking for interested F.A.P.ers to help them potentially improve the way we treat this disease! Here I briefly give some background on clinical trials, including this current F.A.P. geared one (and try and explain my recent absence from this channel). If you also would like to further get involved with health advocacy and this clinical trial, the info below is up your alley: canprevent.com/faptrial clinical@canprevent.com

I say "you know" a gazillion times in this video and maybe you do indeed know how to continue to talk about F.A.P. when it's (fortunately) sort of in a stable state and has been so for a while. Talking about chronic illness can be challenging but, oddly, I've found it's even more difficult to discuss in this sick but, stable state where I (fortunately) have not had any new major medical developments in a while and thus, no new material to help me frame the conversation. Let it be noted that I would happily stay in this weird, frustrating, not quite sure what to say state eternally if it meant that I didn't have to deal with any additional health issues.

After people find out about my lack of colon, they usually inquire about what medicine I'm taking. I decided to go through my medicine cabinet and pull out all of the med-related things I've acquired since being diagnosed with F.A.P. to show you that I'm not a frequent pill popper (at least not yet). I also mentioned some medications that although I'm not taking, I still wanted to draw your attention to since they are being investigated as useful agents for dealing with certain aspects of F.A.P.

The third installment in the F.A.P.ology101 mini-series which goes over how F.A.P. is diagnosed.

The second video in my F.A.P.ology101 mini-series which looks at what's referred to as the main "treatment" for F.A.P. which is the surgical removal of one's colon. Don't forget to subscribe for more FAPulous TV!

This is the first video of the F.A.P.ology101 mini-series I plan on creating which will hopefully provide you with a crash course on what F.A.P. is. It will focus more on what the disease looks like than what it's like living with the disease. In this particular video, I talk about what information we can learn about F.A.P. by examining at its name! Look out for future videos that will cover symptoms, "treatment" options, how it's diagnosed and managed, etc.

Greetings! This is an update on my desmoid and the clinical trial I'm currently doing at NIH. You can now follow me on twitter @gutlesswarrior and check +Angee Casiano's desmoid vlog!

Update on clinical trial news, Moffitt adventures & throwback Thursday! I found old video updates I recorded earlier... ie one is from during radiation! I'll be uploading videos as I can!

This is the start of my v-blog where I'll discuss what it's like to live with a rare genetic disease. I'll cover various topics from what it is, how a person gets it and how its "treated". I want to give a shout-out to http://www.youtube.com/user/FAPulousTV, I probably would have never thought to speak out if I hadn't magically come across her videos.

Sorry it's taken so long for me to upload another v-blog, but I was hit with the horrid news of having a Desmoid Tumor in my lower left pelvic area/abdominal wall. 2013 has been spent treating this bad boy with just about everything under the sun from chemo to radiation and back again... Hopefully I'll be able to keep on v-blogging and educating on a topic that is truly near and dear to me. My dream is to one day maybe become an educational speaker about not only FAP/Gardner's Syndrome, but patient advocacy!

This is just a quick video re: important issues, they are important for everyone! There will be more vids for each topic. If there is a topic you want covered please comment and I'll do my very best

Just another update regarding life with a desmoid tumor and the various treatments and consequences of treatments.... aka hand-foot syndrome SUCKS!

This video gives an overview of some of the extra-colonic manifestations of F.A.P. that people with F.A.P. could encounter down the road. Although it's a bit depressing hearing about all of these unfortunate complications, it's super important to be aware of the other problems associated with F.A.P. so we can make sure we're screened appropriately! I am not a medical doctor so the information presented in this video was obtained through my own research and communication with people in the medical community.

Each year, about 500,000 Americans have to have their colons removed. Whether it’s because of cancer, trauma, diverticulitis or an inflammatory disease, colectomy may be necessary to save their lives. That was the case for Luis, a special young man who came a long way for help. His surgical team at Mayo Clinic found a very special solution. Here’s Dennis Douda for the Mayo Clinic News Network.

I say "you know" a gazillion times in this video and maybe you do indeed know how to continue to talk about F.A.P. when it's (fortunately) sort of in a stable state and has been so for a while. Talking about chronic illness can be challenging but, oddly, I've found it's even more difficult to discuss in this sick but, stable state where I (fortunately) have not had any new major medical developments in a while and thus, no new material to help me frame the conversation.

Adenomatous Polyposis Syndromes Icahn School of Medicine

New Study at Johns Hopkins to explore the role of Curcumin for the prevention of polyps in individuals with familial adenomatous polyposis (FAP)

Professor, Internal Medicine Specialties: Gastroenterology, Internal Medicine Clinical Interests: Dr. Carethers' clinical interests are familial colon cancer syndromes, including familial adenomatous polyposis (FAP), Gardner, Peutz-Jeghers, Lynch, hereditary nonpolyposis colorectal cancer (HNPCC), juvenile polyposis, hyperplastic polyposis, and colorectal cancer.

Presented by Drs. Randall Burt and Jewel Samadder of the Huntsman Cancer Institute's High Risk Colon Cancer Clinic, this webinar covers key topics every gastroenterologist and GI resident should be aware of when diagnosing or providing care to patients symptomatic of APC-related diseases (Familial Adenomatous Polyposis and Attenuated-FAP) or MUYTH-Associated Polyposis (MAP). Key topics include: - Risk assessment, including screening and testing options, for early diagnosis - The role of genetic counseling - Prophylactic treatment and surgical options - Options for reducing and/or preventing polyp growth - When, where, and how to refer a patient to an expert facility and what to expect in coordinating the follow up care you provide This webinar will improve your ability to provide prophylactic treatment to your patients and successfully decrease the instances of cancer.

Companion slideshow to the polypolyp.com website. The website is designed to assist in polyposis

Abstract: Fundic gland polyps are the most common gastric polyps, accounting for half of all gastric polyps, most commonly occurring in middle-aged women; they vary from 2 to 5 mm in size and are either single or multiple. Sporadic fundic gland polyps (FGPs) are benign gastric polyps without any malignant transformation and therefore do not require follow-up or treatment. In patients with polyposis syndromes, especially familial adenomatous polyposis, the incidence and burden of FGPs is markedly increased.

Surveillance for a Family History of Colorectal Cancer

Case discussions in polyposis by Douglas Riegert-Johnson, Physician at Mayo Clinic

Rebecca Haslam, 25, has a rare genetic condition called 'familial adenomatous polyposis ( F.A.P) which leads to growths developing, causing bowel cancer. Rebecca has had life saving surgery to remove the affected parts of her bowel, but now has inoperable tumours. Doctors have said that Rebecca's 5 year old daughter,Tyeshia, will be tested in the future as there is a 50% chance that the condition will be passed onto her. Rebecca joined forces with musician Phil Jones (Afraid of Mice / Up and Running) who wrote and produced a song to raise money for Rebecca's charity to raise funds for St Marks Hospital who specialise in research and treatment for this condition. The song was recorded by 17 year old Charlotte Gallagher.

Travis H. Bray is a third generation F.A.P. survivor and understands firsthand the long-reaching physical and emotional effects living with this disease has on both the patient and their loved ones. By drawing upon both personal experiences with F.A.P. and those of his extended family, he is motivated to developing a support net for those born or affected by F.A.P. Travis graduate with top honors for his graduate work in Actinide Chemistry at Auburn University in 2008. He continued his research for two years as the Berkeley Actinide Postdoctoral Fellow at Lawrence Berkeley National Laboratory, and a third year of post-doctoral research at Argonne National Laboratory. Travis stepped away from his career as a chemistry researcher (June, 2012) to found the Hereditary Colon Cancer Foundation.

Knowledge is power! Help us create a portal that can extend life expectancy, enhance life quality, and instill hope in hereditary colon cancer patients.

Dr. Roberd Bostick is a professor of epidemiology at Rollins School of Public Health and Professor of Hematology and Medical Oncology at Emory University's School of Medicine and Winship Cancer Institute. Dr. Bostick is interested in a wide range of topics surrounding the epidemiology of cancer and cancer biomarkers. He is working to help develop simple tests that would indicate a person was at risk for developing cancer. In this interview he talks with us about his research into the relationship between diet and cancer. He also discussed the important topic of how the public should interpret medical information presented in the news and popular press.

This is my first video. This is from my experience and knowledge that I have gained about F.A.P. (Familial Adnenomatous Polyposis) Please comment or you can email me supersoaker82@gmail.com. Also please subscribe to my F.A.P

Cancer Prevention Pharmaceuticals is developing an investigational drug to treat Familial Adenomatous Polyposis - Jeff Jacob, CEO, invites you to learn about CPP's Phase III Trial.

Adenomatous polyposis coli tumour suppressor Buchi Okereafor

Colorectal Cancer Basics : What is "familial adenomatous polyposis" syndrome or "FAP"? Richard E. Gould, MD, (Hematologist/Oncologist, Cedars-Sinai Outpatient Cancer Center)

Carol Burke, MD, FACG, FASGE, discusses pediatric familial adenomatous polyposis (FAP) and colorectal cancer at the 2014 ACG Annual Scientific Meeting in Philadelphia, PA. She shares her expertise in inherited colon cancer syndromes and comments on some management practices. Burke said, “all the research related to the use of anti-inflammatories in FAP have shown a mild reduction in disease burden, but it’s not a home run yet.” - See more at: http://www.hcplive.com/conference-coverage/acg-2014/Discussing-Pediatric-Familial-Polyposis-and-Colorectal-Cancer#sthash.3VqSsIaF.dpuf

Andrew Fourounjian and his three daughters, Alison, Nicole and Krista, share a rare genetic condition called familial adenomatous polyposis that puts them at 100% risk for colon cancer. Thanks to multiple surgeons at NewYork-Presbyterian/Weill Cornell and ongoing care and monitoring by the multidisciplinary team of the Jay Monahan Center for Gastrointestinal Health, the Fourounijan family can expect to also share many joyous family occasions.

1. Familial Adenomatous Polyposis By: Luke Pardy 2. Chromosome with FAP: This disorder is located on the long arm part of chromosome number 5 3. Name of gene and protein coded for by gene: The name of this gene is the APC gene or Adenomatous Polyposis Coli. The protein coded for by this gene helps with cell adhesion and signal transduction. The mutation will cause the protein to be shorter and will not be able to function.

A full colonoscopy performed from the cecum to the rectum in retroflexed maneuver in a familial adenomatous polyposis coli Classic familial adenomatous polyposis (called FAP or classic FAP) is a genetic condition. It is diagnosed when a person develops more than 100 adenomatous colon polyps. An adenomatous polyp is an area where normal cells that line the inside of a person's colon begin to make mucous and form a mass on the inside of the intestinal tract. The average age for polyps to develop in people with FAP is in the mid-teens. More than 95% of people with FAP will have multiple colon polyps by age 35. If FAP is not recognized and treated, there is almost a 100% chance that a person will develop colorectal cancer. The risk of colon cancer is 87% by age 45. There is also an increased chance of developing cancer in the stomach and/or small intestines. Other types of cancer found in families with FAP include hepatoblastoma (a type of liver cancer seen in young children); papillary thyroid cancer; pancreatic, adrenal, and bile duct cancers; and a low risk of a type of brain cancer called medulloblastoma.

Author Patrick Lynch discusses his article "Global Quantitative Assessment of Colorectal Polyp Burden in Familial Adenomatous Polyposis using a Web-based Tool" from the March issue.

Supporting Families with Cancer Lifestyle and Cancer Awareness Workshop 4, University of Leicester, 12 October 2013 - Curcumin (Turmeric) and Chemoprevention for FAP (Familial adenomatous polyposis) by Dr Lynne Howells and Dr Joey Wood, University of Leicester and University Hospitals of Leicester NHS Trust. A talk about current research into the use of compounds found in food (including Turmeric) for the prevention of cancer. Sorry for the poor video and sound quality. More information is available on our Supporting Families with Cancer website, www.le.ac.uk/sfwc

Bradley Cooper - Limitless movie with FAP clip

Rebecca Haslam, is a 26 year old mum from Orrell Park,she has a 5yr old daughter. Rebecca has desmoid tumours & Familial Adenomatous Polyposis (F.A.P ) which is a rare genetic bowel disorder that currently has no cure. She has had life saving surgery to remove the affected parts of her bowel but now has inoperable tumours. Rebecca wants to raise funds so a cure can be found so her daughter and others wont suffer this diasease. A concert was organised at The Olympia by Pat Hughes,in order to raise funds for St Marks Hospital Foundation charity , who are researching this form of bowel cancer.. Artists who performed free were Half Cut Harry Tutu Charlotte Gallagher Amy Lang The Jones Boys Mic Lowry The Spares Electro 80 Matthew James Breen The show was compared by Phil Windever and Knotty Ash Community centre provided much of the technical equipement free Phil Jones formerly of Up & Running & Afraid of mice, having met Rebecca and listened to her story/emotions he wrote a song especially for Rebecca. The song called " On Better Days "was recorded by 17yr old Charlotte Gallagher who also appeared in the live concert at the Olympia. For details on the charity or how to buy the record contact Pat Hughes 07811779760

1. SCAN AND FOLLOW BARCODE TO LINK OF UPDATED PRESENTATION. 2. GENETIC COLON CANCER SYNDROMES: ANSWERS TO FREQUENT QUESTIONS REGARDING FAMILIAL A. POLYPOSIS AND LYNCH SYNDROME DOUGLAS RIEGERT-JOHNSON, MD MAYO CLINIC FLORIDA RIEGERTJOHNSON.DOUGLAS@MAYO.ED

1. BENIGN TUMORS OF LARGE INTESTINE By: Ismah Haron 1 2. Adenomatous Polyps • Asymptomatic • Association of symptoms and risk of malignancy with increasing of size; colonic bleeding, diarrhea, mucus discharged • Colonoscopy; sessile, pedunculated or mixed • HPE; Tubular, tubulovillous or villous type • Resection (e.g. adenoma > 5 mm)

Polyposis syndromes in colorectum

Companion slideshow for polyppolyp.com (Familial adenomatous polyposis)

The Pilon family is dealing with a family health crisis. Please help them as they have paid it forward in so many ways, and so many times for others. - created at http://animoto.com

Familial Adenomatous Polyposis (or FAP)

Laparoscopic Total Abdominal Colectomy for Familial Adenomatous Polyposis

Three New Jersey sisters inherited familial adenomatous polyposis (FAP), a genetic syndrome that can only be treated by prophylactic removal of the entire colon. Here's their story.

This is a humorous review of the pathology of familial adenomatous polyposis that is aimed at pathologists and pathology residents.

Learn the key differences between Hereditary Nonpolyposis Colorectal Cancer (HNPCC) and Familial Adenomatous Polyposis (FAP).

Familial syndrome and their pathogenesis taht are associated with formation of colon polyps. Puetz Jeghers are Autosomal Dominant. Multiple hamarotomatous polyps and you get a mucocutanoues pigmentation on the face. Complications: Intusseception (fatal) as well as some malignancies, such as breast, ovarian and other cancers. Pathogenesis: it is linked iwth LKD1 and STK11 gene which causes it to decrease. Familial Adenomatous Polyposis (FAP) found on chromosome 5p. THey have multiple polyps throughout the colon. THere are some variants: Gardner - it is also associated osteomas, retinal hypertrophy, and also there is teeth in the mouth Turcot - associated with CNS tumors, medulloblastoma, pheoblastoma. Hereditary NonPolyposis Colon (HNPCC). Also autosomal dominant. Pathogenesis is problem in mismatch repair gene. Associated with MSH2 and MLH1. Increase Short Tandem Randoms. Colon Cancer Pathogenesis FAP model and HNPCC mdoel FAP - mutation in APC then there is two hit. APC generally inhibit B-Catenin which is responsible for activated cyclin D1. Activates mutation of KRas and final hit of p-53 HNPCC model there is mismatch repair which leads to accumulation of gene factor Risk factors is diet, low Vitamin A, C, K. Tobacco, Smoking, Inflammatory Bowel Disease, Puetz Jeghers, FAP, Villous adenoma for developing colon Cancer Clinical Findings and Symptoms: Iron Deficiency Anemia especially in ascending colon, which will be some sort of exophytic mass. Colicky pain and hematochezia if found in descending colon. Mass will be more infiltrative inwards, not outwards. Diagnosis Iron Deficiency in elderly, you must rule out Colon cancer Apple Core lesion on X-ray CEA as tumor marking

A review of the stomach polyps seen in patients with familial adenomatous polyposis.

Lab7 Familial Adenomatous Polyposis (FAP)

Preview this 2015 DVD on a variety of hereditary polyposis syndromes including hereditary nonpolyposis colorectal cancer, familial adenomatous polyposis, Peutz Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, and serrated polyposis syndrome with an emphasis on the gastrointestinal manifestations of these diseases. The DVD focuses on the endoscopic appearance of these diseases in the GI tract and the endoscopic management of such diseases. Find this video online - http://portal.asge.org/products/detai... ASGE videos feature live-action endoscopic videos, complemented by expert instruction on the latest topics. Most releases also offer the ability to earn valuable CME credits. To purchase the full length DVD and other clinical education videos, visit ASGE's Endoscopic Learning

familial adenomatous polyposis. Laparoscopic total proctocolectomy with j-pouch ileoanal anastomosis

Surveillance gastroscopy in patient with FAP who has already had a pan-proctocolectomy.

Health promotion by a student nurse towards a fictional patient with FAP.

endoscopy done at gastroenterology unit ayub teaching hospital abbottabad by Dr. Adil Naseer Khan Head of department

A colonoscopy performed in retroflexed maneuver from the cecum to the rectum. in a patien with Familial Adenomatous Polyposis of the Colon.

Attenuated Familial Adenomatous Polyposis (FAP) Colonoscopy of a 37 year old fan with strong family history of colon cancer and polyps. There are dozens of small sessile polyps in the colon, predominantly in the ascending and transverse colon. The rectum is spared. Some of the polyps are quite subtle but there are at least 40.

Travis Bray of the Hereditary Colon Cancer Foundation was pleased to join Carol Burke, MD of the Cleveland Clinic in a live chat with Cancer Prevention Pharmaceuticals regarding the FAP 310 Clinical Trial.

This podcast discusses the inherited condition known as Familial Adenomatous Polyposis characterized by the development of abnormal growths called polpys in the lining of the large intestine. It describes how a mutation in a gene (in this case the APC gene) leads to the development of this adenomas (in other words polyps) and how the inheritance of this mutation can be observed in a family and adequate early screening can be done to increase chances of survival. This inherited condition has been linked to approximately 1 in100 cases of bowel cancer

In this video we discuss the Wnt / Beta-catenin pathway and its involvement in cancer. specifically we look at its involvement in Familial Adenomatous Polyposis part 3

There are ileostomy options and an ileostomy reversal. This information is for people who need to undergo removal of their large intestine (colon) and rectum (proctocolectomy) -- usually for Ulcerative Colitis or Familial Adenomatous Polyposis. It is also for people who have already had surgery and are living with the type of ostomy called an ileostomy who are candidates for ileostomy reversal surgery. It is also for people with a malfunctioning Kock pouch or failed J-pouch.

Travis and Shawnie Bray, Founders of the Familial Adenomatous Polyposis Foundation were interviewed regarding the mission of the Foundation and the upcoming fundraising event: It Takes Guts! 21 Day Challenge.

In this video we discuss the Wnt / Beta-catenin pathway and its involvement in cancer. specifically we look at its involvement in Familial Adenomatous Polyposis part 4

Laparoscopic Assisted Restorative Proctocolectomy for Familial Adenomatous Polyposis

In this video we discuss the Wnt / Beta-catenin pathway and its involvement in cancer. specifically we look at its involvement in Familial Adenomatous Polyposis. Part 2

From ASCO 2011 -- A discussion with Eric Charsky, disabled veteran, cancer survivor, and Founder and CEO of Volontie

In this video we discuss the Wnt / Beta-catenin pathway and its involvement in cancer. specifically we look at its involvement in Familial Adenomatous Polyposis

Panel A shows the endoscopic appearance of early FAP adenomas; panel B shows the endoscopic appearance of established, multiple, FAP adenomas

A composite drawing showing a close-up image of a freckle on the retina of a patient with colon polyp syndrome.

J-Pouch, S-Pouch, W-Pouch

Ileorectal anastomosis (IRA)

Procedure for construction of an IPAA

Partial Colectomy

TYPES OF COLON POLYPS

How a colon polyp progress to cancer

Spigelman classification for duodenal polyposis in FAP

familial adenomatous polyposis of colon

Familial adenomatous polyposis, total colectomy specimen. The colonic mucosa is studded with innumerable sessile and small pedunculated polyps, which involve the entire length of the specimen

Who to test for FAP & MAP

Familial Adenomatous Polyposis (FAP)

Colon in familial adenomatous polyposis

Clinical and genomic features of a case with a novel APC mosaicism. (a) Colonic adenomatous polyposis and fundic grand polyps of the colon. (b) Pedigree chart. DNA from the peripheral lymphocytes of the parent-proband trio (proband, AGFAP001-1; his father, AGFAP001-2; and his mother, AGFAP001-3) was used for the APC mutation analysis using deep sequencing. (c) Confirmation of the c.834+2T>C mutation by Sanger sequencing using DNA from normal colonic mucosa (subject 1 and 2; arrowheads) and colonic adenomatous polyp (subject 1 and 2; arrows). (d) Transcriptional analysis. Because we detected a mosaic mutation at the spliced donor site (Table 1), the mutation was potentially capable of resulting in an extended amino acid translation at intron 7. We detected an RT–PCR product using electrophoresis that was transcribed into an aberrant mRNA with intron 7. (e) Direct sequencing followed by TA cloning revealed that the c.834+2T>C mutation induced aberrant transcription and produced a truncated APC protein. ☆the stop codon (TAA). mRNA, messenger RNA.

Familial Adenomatous Polyposis

“Screening for Colorectal Cancer: It’s the Right Choice” Infographic

The gross appearance of a villous adenoma is shown above the surface at the left, and in cross section at the right. Note that this type of adenoma is sessile, rather than pedunculated, and larger than a tubular adenoma (adenomatous polyp). A villous adenoma averages several centimeters in diameter, and may be up to 10 cm. On colonoscopy, a sessile polyp is seen below.

A microscopic comparison of normal colonic mucosa on the left and that of an adenomatous polyp (tubular adenoma) on the right is seen here. The neoplastic glands are more irregular with darker (hyperchromatic) and more crowded nuclei. This neoplasm is benign and well-differentiated, as it still closely resembles the normal colonic structure

Here is another example of polyposis with numerous small polyps covering the colonic mucosa. In this particular case, there were osteomas of the skull, a periampullary adenocarcinoma, and epidermal inclusion cysts. Thus, this is a case of Plenk-Gardner syndrome. As with familial adenomatous polyposis, the inheritance pattern is autosomal dominant, with a faulty adenomatous polyposis coli (APC) gene.

This is familial polyposis in which the mucosal surface of the colon is essentially a carpet of small adenomatous polyps. Of course, even though they are small now, there is a 100% risk over time for development of adenocarcinoma, so a total colectomy is done, generally before age 20.